A clinical trial published in the Nutrients journal found that 12 weeks of oat straw extract supplementation (at a dosage significantly higher than that in Alpha Brain) caused no cognitive improvement. The third ingredient in the Flow Blend is oat straw extract. Here are three studies suggesting that tyrosine may aid cognitive function, but the lowest dose in any of them is equivalent to around 10,000 mg for an average weight adult. The average ingredient dose in Flow Blend is 162.5 mg, or around 2% of what appears to be an effective nootropic dose. This compound has been studied more for nootropic effect than l-theanine, but we consider it likely to be underdosed in Alpha Brain. The second item in this blend is another amino acid, l-tyrosine. We consider this to be a potentially effective nootropic ingredient for individuals with anxiety, but a likely ineffective nootropic ingredient for individuals without anxiety. That claim on their website is not cited, but due to the similar terminology it seems as though the brand is referencing this medical study titled “Effects of l-theanine on attention and reaction time response.” The study found that l-theanine had “no convincing effect” in healthy subjects, and had a nootropic effect on subjects with anxiety. Onnit claims that amino acid l-theanine is “shown to promote attention and reaction time” which is a surprising claim in our opinion, given that l-theanine is typically used as an anxiolytic (for anxiety reduction). The first ingredient blend in Alpha Brain is called “Flow Blend” and contains four active ingredients at a combined dosage of 650 milligrams (mg). In this article we’ll analyze Alpha Brain’s formulation, as well as the two published medical studies on the supplement, to give our take on whether it's actually likely to improve cognition and memory, or if it's a waste of your money.Īlpha Brain contains a large number of active ingredients, so we'll break our ingredient review into four sections based on the four sections of the Supplement Facts label: Flow Blend, Focus Blend, Fuel Blend and other active ingredients. The supplement is made famous by Joe Rogan, who claims Alpha Brain significantly improves his mental state and references the product frequently on his podcast "The Joe Rogan Experience." We recommend that patients follow their doctor’s guidance in regard to nootropics.Īlpha Brain is a nootropic supplement manufactured by a company called Onnit. Disclaimer: None of the information in this article constitutes medical advice, and is just the opinion of the writer(s).
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